Endocrine Abstracts

Introduction: Hyperprolactinaemia may be associated with weight gain and obesity, suggesting that prolactin may modulate body composition and weight. Treatment that normalises prolactin levels using dopamine agonists frequently leads to weight loss and provides further evidence for the association.Case: A 28-year-old South Asian male with a body mass index of 27.2 kg/m2 was referred to a weight management clinic with a five year history of wei...

Introduction: Increasing evidence shows that type 2 diabetes mellitus (T2DM) could be reversible and that this is related to weight loss. Significant weight loss achieved through bariatric surgery or medically can result in diabetes remission. Diabetes remission is more likely to occur in those who are younger, have shorter duration of disease, and are on fewer diabetes medications. The impact of using a low energy formula-based diet in combination with physical activity on T2...

Introduction: Type 2 Diabetes Mellitus (T2DM) and obesity are a serious health challenge. Obesity and metabolic disorders are associated with cardiovascular risk. Several studies have suggested that low vitamin D status contributes to insulin resistance. This study aimed to explore vitamin D and its relationship with cardio-metabolic risk factors in those with early T2DM.Methods: Early T2DM subjects (N=139) with early T2DM, ≤ 3 years, were...

It is important for a specialist weight management service to provide a holistic patient-oriented assessment and treatment plan. To achieve this goal, we performed a service evaluation of the characteristics of patients with extreme and complex obesity attending a specialist weight management service. Anonymised data on 126 patients who attended the Heart of England NHS Foundation Trust specialist weight management service were collected. The patients, with mean age 45.2±...

Introduction: T2DM (type 2 diabetes mellitus) appears to worsen the course of NAFLD (Non-Alcoholic Fatty Liver Disease) and NAFLD can make diabetes management more challenging. Long-term, NAFLD can lead to liver fibrosis, steatohepatitis, cirrhosis, and end-stage liver disease. This study aimed to examine factors associated with NAFLD measures in early T2DM.Methods: Subjects (n=144) with early T2DM (<=3 years) and obesity (BMI>=27 kg/m<s...

Background: From population studies, short and long sleep duration are associated with obesity. This association has not been studied in patients with type 2 diabetes (T2D).Methods: Design: Cross-sectional study of adult T2D patients recruited randomly from outpatient department of a large UK tertiary centre. Patients with known sleep-related disorders were excluded. Data were collected during one-to-one interviews. Sleep duration assessment: 7-day sleep...